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Home - Products - Chromatin/Epigenetic - Sirtuin - SIRT7 inhibitor 97491

SIRT7 inhibitor 97491

CAS No. 1807758-81-1

SIRT7 inhibitor 97491 ( —— )

Catalog No. M28213 CAS No. 1807758-81-1

SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SIRT7 inhibitor 97491
  • Note
    Research use only, not for human use.
  • Brief Description
    SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
  • Description
    SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.(In Vitro):SIRT7 inhibitor 97491 decreased SIRT7 activity in a dose-dependent manner. SIRT7 inhibitor 97491 induced expression of p53 and its acetylation by inhibited SIRT7. SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells.(In Vivo):In xenograft mice, SIRT7 inhibitor 97491 (2 mg/kg; i.p) inhibited tumor growth. SIRT7 inhibitor 97491 upregulated apoptotic effects through the caspase related proteins and inhibited cancer growth in vivo.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    β-Lactamase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1807758-81-1
  • Formula Weight
    285.7
  • Molecular Formula
    C15H12ClN3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Nc1cccc(Nc2ncc(-c(cc3)ccc3Cl)o2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Papp-Wallace KM, et al. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J Med Chem. 2018 May 10;61(9):4067-4086.
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